I agree with the 'crab.
As a culture Japan is very casually racist. Not particularly malicious, but racist all the same. Look at the relationship with Korea (although that is mutual) and the treatment of the indigenous Ainu.
Also the general distrust of Westerners when it comes to anything other than imported entertainment (and even then... see the general distrust of the Xbox and otherwise inexplicable poor sales of American games machines).
Even if you are a gifted Japanese speaker, and expert in your field, it is extremely difficult to get the kind of job and salary you deserve in Japan unless you work for a Western company. You will always been seen as an outsider, and someone who doesn't belong.
This outlook is engrained, and simply a part of Japanese culture. Not particularly malicious in the general intent, but pervasive.
To steer this back to video games, see also Robin Banks in the Japanese version of DecAthlete:
http://uk.retro.ign.com/articles/898/898248p1.htmlI'm a big fan of Japanese popular culture generally by the way, and buy a fuck-ton of import video games. None of this really means that RE5 is racist either, my view is that Capcom's promotional material is a bit ignorantly insensitive at absolute worst, but I expect nothing particularly offensive in the game itself. Apart from the quality of the voice acting.