There are loads of games based off of 'adult' cartoons from the 90s. I'm specifying 'adult' or I'll be here all day and can't be arsed.
The Simpsons
Obviously has by far the most games based off of it. I had Bart's Nightmare, which is a sort of minigame collection where you go into different dreams trying to get Bart's homework back. Here's a fact about the game from Wikipedia: "Company meddling during the development of the game prompted Bill Williams, the game's designer, to leave the video game industry."
I also had Virtual Springfield, which wasn't really a game but more of an interactive CD-ROM experience. It wasn't very good and looked shite, really scratchy and cheap, but I loved it. I'd go to the Stonecutter's Mansion and just sit listening to the song. You could play some of the arcade games like Larry the Looter and Slugfest. It also had a lot of new voice acting from the full cast including Phil Hartman. Wouldn't mind playing this again actually.
Hit & Run is meant to be good isn't it? Don't know. What about The Simpsons Game (which came out around the same time as the film)? I remember reading it was a good parody of games.
Tapped Out isn't a game.
South Park
When I was in school and we were all going mental for South Park they brought out an FPS on the N64 and we went MORE MENTAL. The two best things in the world, South Park and N64 Goldeneye, brought together. You could throw a snowball, and you could wee on the snowball and it would turn yellow! Well it was a load of shit. There was also a Mario Kart knock off which was presumably shit as well.
But The Stick of Truth was really good, I thought. Doing a sort of Paper Mario knock off was a great idea, and being able to make it look exactly like the show instead of using weird 3D versions of Cartman and his crazy friends really helped. I haven't played Fractured But Whole. They made the combat more complicated? Not sure about that, I wasn't playing the first one for the deep combat. I wanted to see Mr Hankey.
Beavis & Butthead
There are three Beavis & Butthead games about Beavis & Butthead trying to get tickets to see Gwar. Mega Drive, SNES and Game Gear. I don't think I've played them but I definitely read the walkthroughs for both the MD and GG versions in a Sega magazine. I used to read walkthroughs like stories, like a sort of proto-streaming. I thoroughly enjoyed the escapades of Beavis & Butthead.
There's a later game called Virtual Stupidity. Never played it but they released the minigames as a separate thing called Little Thingies and I had that somehow. You could spit on people off a roof and Beavis & Butthead would laugh and say they needed TP for their bungholes. My dad was very cross when he found it on the PC and told me off. I moved it to some other folder so I could still spit on people off a roof and laugh about needing TP for my bunghole.
Futurama
The game of this seemed like basically the only chance we'd ever have of seeing more Futurama when it got cancelled (the first time) so I played it all the way through even though it was a pain in the arse. You can watch all the cutscenes on the DVD of one of the films. This is also a pain in the arse. More recently they did some shite phone game but times aren't as desperate as they once were so I haven't played it and I never ever will.
Family Guy
I thought there was just a Tapped Out style phone game but actually there are two proper games of Family Guy. Are they any good? No idea. Will I find out for myself? No. Hopefully some lunatic will come in here and say if they're good.
There's some Ren & Stimpy games too but fuck knows about that.