Author Topic: Sourced Coronavirus Information & Links  (Read 11234 times)

Zetetic

  • Worrying the carcass of an old song.
Re: Sourced Coronavirus Information & Links
« Reply #240 on: April 14, 2020, 02:02:33 PM »
England-only.

Re: Sourced Coronavirus Information & Links
« Reply #241 on: April 14, 2020, 02:04:34 PM »
Oh yeah, sorry.

Was looking for mine so didn't really pay attention.

Head Gardener

  • weed specialist
    • Gardening mixes
Re: Sourced Coronavirus Information & Links
« Reply #242 on: April 14, 2020, 03:37:23 PM »

Re: Sourced Coronavirus Information & Links
« Reply #243 on: June 04, 2020, 10:02:10 AM »
Male pattern baldness? You will probably get Covid-19 worse.

Quote
In January, one of the first publications on those sickened by the novel coronavirus in Wuhan, China, reported that three out of every four hospitalized patients were male. Data from around the world have since confirmed that men face a greater risk of severe illness and death from COVID-19 than women and that children are largely spared. Now, scientists investigating how the virus does its deadly work have zeroed in on a possible reason: Androgens—male hormones such as testosterone—appear to boost the virus’ ability to get inside cells.

A constellation of emerging data supports this idea, including COVID-19 outcomes in men with prostate cancer and lab studies of how androgens regulate key genes. And preliminary observations from Spain suggest that a disproportionate number of men with male pattern baldness—which is linked to a powerful androgen—end up in hospitals with COVID-19. Researchers are rushing to test already approved drugs that block androgens’ effects, deploying them early in infection in hopes of slowing the virus and buying time for the immune system to beat it back.

https://www.sciencemag.org/news/2020/06/why-coronavirus-hits-men-harder-sex-hormones-offer-clues

Re: Sourced Coronavirus Information & Links
« Reply #244 on: June 04, 2020, 12:43:15 PM »
All it needs now is a link to Phimosis and CAB is as good as dead

Re: Sourced Coronavirus Information & Links
« Reply #245 on: June 10, 2020, 01:55:33 PM »
Blood type A? You will probably get Covid-19 worse.

Quote
Research published last week prior to peer review suggested blood type may play a role in the severity of patients’ reactions to SARS-CoV-2. That study looked at the genes of more than 1,600 patients in Italy and Spain who experienced respiratory failure and found that having type A blood was linked to a 50% increase in the likelihood a patient would require a ventilator. An earlier Chinese study turned up similar results regarding a person’s susceptibility to Covid-19.

The research found that individuals with type O blood are between 9% and 18% less likely than individuals with other blood types to have tested positive for the virus. However, there was little difference in susceptibility among other blood types, the study found. When the researchers adjusted the data to account for factors like age and pre-existing illnesses, as well as when it restricted the data to only those with high-probability of exposure like health-care workers, the findings were the same.

https://www.bloomberg.com/news/articles/2020-06-08/23andme-provides-more-evidence-that-blood-type-plays-role-in-virus

KennyMonster

  • Dance like The Goverment is watching.
Re: Sourced Coronavirus Information & Links
« Reply #246 on: June 10, 2020, 02:55:55 PM »
I am very interested in not getting this virus and I will live like a hermit until there's a vaccine.


Ooooh "vaccine, vaccine, vaccine", that's all I bloody hear about!

Are my anti-Covid Immunoglobulins not good enough for ya?

Re: Sourced Coronavirus Information & Links
« Reply #247 on: June 10, 2020, 03:52:14 PM »
Haha too bad type A 🤣🤣🤣

Re: Sourced Coronavirus Information & Links
« Reply #248 on: June 27, 2020, 12:06:33 PM »
Some interesting things I read this week.

They're getting more of an understanding of how the virus affects the immune system, which has some parallels with HIV in the treatment needed and helps explain why the after-effects go on so long.

Quote
One of the most striking aberrations in Covid-19 patients, the investigators found, was a marked increase in levels of a molecule called IP10, which sends T cells to areas of the body where they are needed.

Ordinarily, IP10 levels are only briefly elevated while T cells are dispatched. But in Covid-19 patients — as was the case in patients with SARS and MERS, also caused by coronaviruses — IP10 levels go up and stay up.

That may create chaotic signaling in the body: “It’s like Usain Bolt hearing the starting gun and starting to run,” Dr. Hayday said, referring to the Olympic sprinter. “Then someone keeps firing the starting gun over and over. What would he do? He’d stop, confused and disoriented.”

The result is that the body may be signaling T cells almost at random, confusing the immune response. Some T cells are prepared to destroy the viruses but seem undermined, behaving aberrantly. Many T cells apparently die, and so the body’s reserves are depleted — particularly in those over age 40, in whom the thymus gland, the organ that generates new T cells, has become less efficient.

https://www.nytimes.com/2020/06/26/health/coronavirus-immune-system.html

It's also affecting the production of insulin, which in some patients is causing them to have diabetes.

Quote
Various viruses, including the one that causes severe acute respiratory syndrome (SARS), have been linked with autoimmune conditions such as type 1 diabetes. And many organs involved in controlling blood sugar are rich in a protein called ACE2, which SARS-CoV-2 uses to infect cells.

The latest clue comes from an experimental study in miniature lab-grown pancreases published last week suggests that the virus might trigger diabetes by damaging the cells that control blood sugar.

https://www.nature.com/articles/d41586-020-01891-8

The virus has been found to use tentacles (filopodia) to better infect nearby cells, something HIV also does.



Quote
The discovery that the coronavirus initiates the sprouting of filopodia in infected cells suggests that it has, at some point in its evolution, developed more than one way to ensure it gets passed quickly from cell to cell.

Typically, a rapid rise in infected cells will raise a victim’s viral load, make her feel sick and promote the transmission of the virus to other people. UC San Francisco’s Nevan Krogan, one of the paper’s senior authors, said there is much about the coronavirus that doesn’t match scientists’ expectations.

But the discovery of filopodia in coronavirus-infected cells suggests that this virus has developed more than one way to wheedle its way into cells and establish itself as a force to be reckoned with.

https://www.latimes.com/science/story/2020-06-26/inside-the-body-the-coronavirus-is-even-more-sinister-than-scientists-had-realized
https://eu.jsonline.com/story/news/2020/06/26/coronavirus-grows-tentacles-inside-cells-providing-clue-treatment/3235414001/

Re: Sourced Coronavirus Information & Links
« Reply #249 on: July 04, 2020, 09:39:42 AM »
Neanderthal heritage? You will probably get Covid-19 worse.

Quote
A recent genetic association study (Ellinghaus et al. 2020) identified a gene cluster on chromosome 3 as a risk locus for respiratory failure in SARS-CoV-2. Recent data comprising 3,199 hospitalized COVID-19 patients and controls reproduce this and find that it is the major genetic risk factor for severe SARS-CoV-2 infection and hospitalization (COVID-19 Host Genetics Initiative). Here, we show that the risk is conferred by a genomic segment of ~50 kb that is inherited from Neandertals and occurs at a frequency of ~30% in south Asia and ~8% in Europe.

https://www.biorxiv.org/content/10.1101/2020.07.03.186296v1

(Not peer-reviewed, only one factor in many.)

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