Seinfeld
Jerry would be hand sanitising, obsessing over hygiene, etc. He'd be dating a woman who constantly flouts social distancing rules, but wouldn't be able to bring himself to break up with her because she's unfeasibly attractive.
George would end up living with his parents again and be miserable. He'd also have an unfeasibly attractive girlfriend who he was planning on breaking up with, but then she gets COVID and he feels he can't break up with her straight away. Then when he thinks enough time has passed, she'd start showing signs of long COVID.
Elaine would be complaining about everybody else failing to practice good hygiene, but then she'd be caught failing to hand sanitise after going to the toilet and would become a pariah.
Kramer wouldn't believe in COVID, but would also be selling masks that he made by cutting up his old shirts. He'd then run out of clothes and have to start borrowing Jerry's.